We stand at the culmination of a technological development that lasted for decades, and went largely unnoticed until recently. It involved many innovations of instrumentation, of sample preparation, and computer processing methods for which this year’s Nobel Prize in Chemistry has been awarded. As a result, molecules which form the basis of life functions in the cell can now be imaged with unprecedented clarity, even at atomic resolution. Their actions as molecular machines can even be analyzed and captured in movies. In this lecture the challenges and milestones leading to a new era in Structural Biology and, eventually, Molecular Medicine will be illustrated.
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