ICTS

This workshop will focus on the topics of the RNA world and evolution of RNA functions. The RNAs interact with various elements of the translation apparatus, and the dynamics of these interactions is a major determinant in the outcome of the fundamental biological processes. We will discuss the roles of noncoding RNAs in catalysis, and in translation of mRNAs. RNA traverses through different structures in a cell during its lifetime. Often, RNAs are sequestered into ribonucleoprotein (RNP) condensates, which not only store them but also determine their fates. The structures of these condensates are conserved, membrane-less and dynamic which assemble via liquid-liquid phase separation (LLPS) of RNA-protein complexes, for instance P-bodies, P-granules, and stress granules. Deficiencies in the dynamics of RNA sequestration into these cellular bodies may result in pathologies, including cancer and neurological disorders. Further, we will discuss the roles of nucleoside modifications and the heterogeneity of their occurrences, in functions of various RNAs. Likewise, although the high-resolution structural determinations of functional complexes of ribosomes have provided crucial mechanistic details of mRNA translation, much remains to be understood about their heterogeneity and mRNA translation. Also, how ribosomes recognize the start (initiation) and end (termination) signals during translation, and how they bypass them in a programmed manner needs to be better understood. The atomistic molecular simulation dynamics studies are being used for deeper understanding of these processes. Discussions on these topics are prerequisites to develop tool kits to intervene in the RNA-centric processes as part of disease management strategies.

Eligibility criteria: PhD students (2nd year onwards), Postdoctoral fellows, Scientists/ Professors (any stage) working in the field of RNA biology.

The application portal will be live on February 15, 2025.

Accommodation will be provided for outstation participants at our on campus guest house.

ICTS is committed to building an environment that is inclusive, non discriminatory and welcoming of diverse individuals. We especially encourage the participation of women and other under-represented groups.

Partially supported by Indian Institute of Science, Bengaluru